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目的对新生儿血小板减少症(NTP)的发病因素以及预后进行系统分析,旨在为更好的防治该病提供参考。方法选取2013年4月-2016年4月在深圳市宝安区福永人民医院接受医治的120例NTP患儿为对象。回顾性总结120例患者的发病因素及预后。结果早发性血小板减少与晚发性血小板减少的人数分别为64例、56例。最主要致病因素,早发性血小板减少是母亲患免疫性疾病(67.2%),晚发性血小板减少是新生儿感染(83.9%)。所有患者均给予相应的治疗,早发性血小板减少患儿治愈64例(100.0%),死亡0例(0.0%)。晚发性血小板减少患儿治愈55例(98.2%),死亡1例(1.8%)。早发性血小板减少与晚发性血小板减少患儿的预后结果差异无统计学意义(P>0.05)。结论新生儿早发性血小板减少与晚发性血小板减少的最主要致病因素分别为母亲患免疫性疾病、新生儿感染。全部患儿没有出现明显的出血症状且预后较好。
Objective To systematically analyze the incidence and prognosis of neonatal thrombocytopenia (NTP), aiming to provide a reference for better prevention and treatment of the disease. Methods From April 2013 to April 2016, 120 children with NTP who were treated in Fuyong People’s Hospital, Bao’an District, Shenzhen City were selected as the subjects. A retrospective review of 120 patients with the risk factors and prognosis. Results The number of patients with early-onset thrombocytopenia and late-onset thrombocytopenia were 64 and 56 respectively. The most important causative agents, premature thrombocytopenia were mothers with immunocompromised disease (67.2%) and late-onset thrombocytopenia (83.9%) with neonatal infection. All patients were given the appropriate treatment, 64 cases of children with early-onset thrombocytopenia were cured (100.0%), 0 cases of death (0.0%). 55 cases (98.2%) were cured and 1 died (1.8%) in children with late onset thrombocytopenia. The prognosis of children with early-onset thrombocytopenia and late-onset thrombocytopenia had no significant difference (P> 0.05). Conclusions The most important risk factors for early-onset thrombocytopenia and late-onset thrombocytopenia are neonatal maternal immunodeficiency disease and neonatal infection. All children did not show obvious bleeding symptoms and the prognosis is good.