肿瘤患者血循环中核酸含量明显高于正常人 ,研究证实其来源于肿瘤细胞 ,并且与原发肿瘤有着结构或功能上的某些一致性 ,因此循环核酸对肿瘤的诊断、治疗和预后评估都可能有重要价值。近年来随着方法学的进步和肿瘤发生分子机制研究的深入 ,循环核酸日益受到重视 ,这方面的研究也逐渐增多 ,现综述恶性肿瘤循环核酸国内外研究现状。 The tumor blood circulation in patients with significantly higher levels of nucleic acid, the study confirmed that it comes from tumor cells, and with the primary tumor has some structural or functional consistency, so the diagnosis of circulating nucleic acid on the tumor, treatment and prognosis assessment may Have important value. In recent years, with the progress of methodology and the deep research of the molecular mechanisms of tumorigenesis, circulating nucleic acids are paid more and more attention. The research in this field is also gradually increasing. Nowadays, the research status of circulating nucleic acids in malignant tumors is summarized.