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应用ＰＡＰ法对６０例大肠癌、癌旁粘膜及正常粘膜进行了癌胚抗原（ＣＥＡ）的免疫组化检测，对大肠癌沿肠管的纵向浸润范围进行了形态学测量。结果显示，ＣＥＡ在大肠癌组织阳性率为９６．７％，明显高于癌旁粘膜及正常粘膜（Ｐ＜０．０１），低分化腺癌ＣＥＡ阳性率明显高于乳头状腺癌和腺癌１级。大肠癌ＣＥＡ阳性程度与沿肠管纵向浸润距离无关。本组病例４１％沿肠管纵向浸润距离在瘤体下缘０．５ｃｍ内，７８％浸润１ｃｍ内，仅１．７％浸润达瘤体下缘２ｃｍ以上。肿瘤浸润越深，纵向浸润距离越大（Ｐ＜０．０１）。浸润方式主要有直接蔓延和淋巴管栓塞。大肠癌沿肠等纵向浸润距离很少超过２ｃｍ，可作为大肠癌手术切除范围的理论依据。
The PAP method was used to detect the carcinoembryonic antigen (CEA) in 60 cases of colorectal cancer, paraneoplastic mucosa and normal mucosa. Morphological measurements were performed on the longitudinal invasion of colorectal cancer along the intestine. The results showed that the positive rate of CEA in colorectal cancer tissue was 96.7%, which was significantly higher than that in paraneoplastic and normal mucosa (P<0.01). The positive rate of CEA in poorly differentiated adenocarcinoma was significantly higher than that in papillary adenocarcinoma and adenocarcinoma. Level 1. The positive degree of CEA in colorectal cancer was not related to the length of infiltration along the intestine. In this group of patients, 41% of the longitudinal infiltration along the intestine in the lower edge of the tumor within 0.5cm, 78% infiltration within 1cm, only 1.7% infiltration of the lower edge of the tumor more than 2cm. The deeper the tumor invasion, the greater the longitudinal infiltration distance (P<0.01). Infiltration mainly direct and lymphatic embolism. The longitudinal infiltration distance of colorectal cancer along the intestine rarely exceeds 2cm, which can be used as a theoretical basis for surgical resection of colorectal cancer.