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目的比较半量和全量注射用伏立康唑治疗重型肝炎并发侵袭性肺曲霉菌病(IPA)的效果。方法回顾性分析32例重型肝炎合并IPA患者的临床表现、实验室检查包括肝功能、PT、胸部CT和治疗转归。结果半量组(7例)有效率为71.43%,全量组(25例)有效率为24.00%。半量组肝功能、胸部CT病灶体积较全量组改善明显(P<0.05)。结论严重肝功能减退的患者应用半量伏立康唑疗效优于全量应用者。
Objective To compare the efficacy of half-dose and full-dose voriconazole for the treatment of severe hepatitis with invasive pulmonary aspergillosis (IPA). Methods The clinical manifestations of 32 patients with severe hepatitis complicated with IPA were retrospectively analyzed. The laboratory tests included liver function, PT, chest CT and treatment outcome. Results The effective rate of half dose group (7 cases) was 71.43%, and that of full dose group (25 cases) was 24.00%. Half of the group of liver function, thoracic CT lesion volume than the whole group improved significantly (P <0.05). Conclusion Severe hepatic dysfunction in patients with half the amount of voriconazole curative effect than the full application.