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目的 探讨儿童焦虑症与5-HT2A受体基因多态性之间的遗传关联。方法 采用聚合酶链式反应(PCR)和限制性片段长度多态性(RFLPs)方法,对61个符合DSM-Ⅳ与CCMD-2-R诊断标准的焦虑症儿童及其父母的5-HT2A受体基因多态性进行分型,分型结果用单体型相对风险方法(CHRR和HHRR)与传递不平衡检验(TDT)进行分析。结果 儿童焦虑症与5-HT2A受体基因无显著性关联。CHRR、HHRR和TDT值分别为2.3607～0.9213,1.0955和1.88,P值均>0.05。结论 儿童焦虑症与5-HT2A受体基因T102C多态性无关联。
Objective To explore the genetic relationship between children with anxiety and 5-HT2A receptor gene polymorphism. Methods Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLPs) were used to detect the 5-HT2A receptor in 61 children with anxiety disorder and their parents who meet the DSM-Ⅳ and CCMD-2-R diagnostic criteria Genotypes were genotyped. The genotyping results were analyzed by haplotype relative risk (CHRR and HHRR) and transmission disequilibrium test (TDT). Results There was no significant correlation between anxiety disorder and 5-HT2A receptor gene in children. CHRR, HHRR and TDT values were 2.3607 ~ 0.9213, 1.0955 and 1.88, P values were> 0.05. Conclusion Children with anxiety disorder have no correlation with 5-HT2A receptor gene T102C polymorphism.