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目的探讨输血相关性肺损伤CD4+CD25+调节性T细胞(Treg)和白细胞介素-10(IL-10)表达与预后的关系。方法 60例急性脑梗死患者作为研究组,同时期健康体检者60例作为对照组,检测CD44+CD25+Treg表面分子T淋巴细胞毒性相关抗原4(CTLA-4)表达;CD4+CD25+Treg孵育液上清中IL-10水平。结果研究组CD4+CD25+Treg表面分子CTLA-4表达率、IL-10水平均高于对照组(P<0.05);多器官功能障碍综合征(MODS)组患者CTLA-4表达率、IL-10水平高于非MODS组(P<0.05);死亡组CTLA-4表达率、IL-10水平明显高于生存组(P<0.05)。结论急性脑梗死患者能够加强CD4+CD25+Treg表面分子表达,其大量分泌能够抑制细胞因子发挥相关,使得免疫功能发生障碍,还会影响免疫紊乱的发生及发展,与预后存在密切关系。
Objective To investigate the relationship between the expression of CD4 + CD25 + regulatory T cells (Treg) and interleukin-10 (IL-10) and prognosis in blood transfusion-associated lung injury. Methods Sixty patients with acute cerebral infarction were selected as the research group and 60 healthy subjects were used as the control group to detect the expression of CTLA-4 on CD44 + CD25 + Treg. CD4 + CD25 + Treg IL-10 levels in the supernatant. Results The expression of CTLA-4 and IL-10 in CD4 + CD25 + Tregs in study group were higher than those in control group (P <0.05). The expression of CTLA-4 and the expression of IL-10 in multiple organ dysfunction syndrome (P <0.05). The expression of CTLA-4 and the level of IL-10 in the death group were significantly higher than those in the non-MODS group (P <0.05). Conclusions Patients with acute cerebral infarction can enhance the expression of CD4 + CD25 + Treg molecules on the surface of the brain, and their large amount of secretion can inhibit the cytokines to play a related role, impair the immune function, affect the occurrence and development of immune disorders and have a close relationship with the prognosis.