论文部分内容阅读
目的 :系统评价胃肠癌组织中亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因C677T位点多态性与含5-氟尿嘧啶化疗方案治疗敏感性的相关性。方法:系统检索PubMed、EBSCO、Web of Science、Cochrane Library、中国生物医学文献数据库、中国知网、维普以及万方数据库,收集有关MTHFR C677T基因多态性与含5-氟尿嘧啶化疗方案治疗胃肠癌敏感性关系的研究文献,检索时限均从各数据库建库至2016年12月。由2位评价者按照纳入与排除标准独立筛选文献、提取资料后,采用Rev Man 5.3软件进行Meta分析,并采用STATA 12.0统计学软件进行敏感性分析和发表偏倚评估。结果:共纳入11项研究,共1 267例胃肠癌患者。携带T等位基因的患者对含5-氟尿嘧啶化疗方案的敏感性明显高于携带C等位基因的患者[比值比(odds ratio,OR)=5.31,95%可信区间(confidence interval,CI)为3.23~8.73,P<0.001]。TT基因型患者对化疗方案的敏感性明显高于CC基因型患者(OR=4.87,95%CI为2.18~10.86,P<0.001)。TT+TC基因型患者对化疗方案的敏感性明显高于CC基因型患者(OR=0.52,95%CI为0.33~0.84,P=0.007)。TT基因型患者对化疗方案的敏感性明显高于CC+TC基因型患者(OR=4.39,95%CI为2.07~9.32,P<0.001)。结论:胃肠癌患者的MTHFR C677T基因多态性与含5-氟尿嘧啶化疗方案治疗敏感性明显相关。
OBJECTIVE: To systematically evaluate the association between the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the sensitivity to chemotherapy with 5-fluorouracil in patients with gastrointestinal cancer. Methods: PubMed, EBSCO, Web of Science, Cochrane Library, China Biomedical Literature Database, CNKI, VIP and Wanfang Database were searched to collect information about MTHFR C677T gene polymorphism and 5-Fluorouracil regimen in the treatment of gastrointestinal cancer Sensitive relationship between the research literature, retrieval time are from the database database to December 2016. Two reviewers independently screened the literature according to inclusion and exclusion criteria. Data were extracted and analyzed using Rev Man 5.3 software for meta-analysis and STATA 12.0 statistical software for sensitivity analysis and publication bias assessment. RESULTS: A total of 1 267 gastrointestinal cancer patients were enrolled in 11 studies. Patients with the T allele were significantly more susceptible to chemotherapy with 5-fluorouracil than those with the C allele [odds ratio (OR) = 5.31, 95% confidence interval (CI) 3.23 ~ 8.73, P <0.001]. The sensitivity of patients with TT genotype to chemotherapy was significantly higher than that of patients with CC genotype (OR = 4.87, 95% CI: 2.18-10.86, P <0.001). The sensitivity of patients with TT + TC genotype to chemotherapy was significantly higher than those with CC genotype (OR = 0.52, 95% CI 0.33 to 0.84, P = 0.007). The sensitivity of patients with TT genotype to chemotherapy was significantly higher than that of patients with CC + TC genotype (OR = 4.39, 95% CI: 2.07 to 9.32, P <0.001). Conclusion: The MTHFR C677T gene polymorphism in patients with gastrointestinal cancer is significantly associated with the sensitivity to chemotherapy with 5-fluorouracil.