论文部分内容阅读
目的通过比较抗环瓜氨酸肽(CCP)抗体和RF因子,研究抗CCP抗体对类风湿关节炎(RA)的早期预测性和确诊率,在病程不同的RA患者中的敏感性率,以及浓度的高低与病情严重程度的关系。方法分别用酶联免疫吸附法(ELISA)和免疫散射比浊法定量检测抗CCP抗体与RF因子的浓度,并对结果进行统计学分析。结果抗CCP抗体在一例RA患者的健康子女中检测出高浓度阳性;未分化关节炎患者中抗CCP抗体确诊率为82.35%,远高于RF的17.65%;在39例早期RA患者中抗CCP抗体阳性率为82.05%,远高于RF的30.77%;在病程大于2年的147例RA患者中抗CCP抗体阳性率为89.12%,低于RF的93.2%;在病程大于2年且放射学显示出现骨质破坏的36例RA患者中抗CCP抗体阳性率为94.44%,高于RF的86.11%,且抗CCP抗体的平均浓度明显高于未骨质破坏的患者。结论抗CCP抗体是一个能及早预示RA、早期鉴别RA并早期确诊RA的优秀指标,并对骨质破坏有很好的提示作用。
Objective To investigate the predictive and confirmatory rates of anti-CCP antibodies for rheumatoid arthritis (RA) and susceptibility rates in RA patients with different duration of disease by comparing anti-cyclic citrullinated peptide (CCP) antibody and RF factor, and The relationship between the level of the disease and the severity of the disease. Methods The concentrations of anti-CCP antibody and RF factor were detected quantitatively by enzyme-linked immunosorbent assay (ELISA) and immunostaining turbidimetry respectively, and the results were statistically analyzed. Results The anti-CCP antibody detected a high positive rate in healthy children of one RA patient. The positive rate of anti-CCP antibody in patients with undifferentiated arthritis was 82.35%, much higher than that of RF (17.65%). In 39 patients with RA, anti-CCP The positive rate of anti-CCP was 82.05%, which was much higher than that of RF (30.77%). The positive rate of anti-CCP antibody was 147.12% in 147 RA patients with the course of more than 2 years, which was lower than 93.2% of RF. In the course of more than 2 years, The positive rate of anti-CCP antibody in 36 RA patients showing bone destruction was 94.44%, higher than that of RF, 86.11%, and the average concentration of anti-CCP antibody was significantly higher than that of non-osteoarthritic patients. Conclusion Anti-CCP antibody is an excellent indicator of RA as early as possible, early identification of RA and early diagnosis of RA, and has a good indication of bone destruction.