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目的:研究三维适形放疗联合氯膦酸二钠治疗骨转移瘤的临床效果。方法:选择2012年8月至2014年4月经我院治疗的42例骨转移瘤患者,将上述患者按照治疗方式的不同分为观察组和对照组。观察组21例给予三维适形放疗联合氯膦酸二钠治疗,对照组21例仅给予单纯三维适形放疗,比较两组治疗的有效率。结果:观察组和对照组疼痛缓解率比较差异有统计学意义(P<0.05);观察组平均起效时间和平均缓解时间分别为(8.0±1.6)d和(25.1±6.0)d,对照组平均起效时间和平均缓解时间分别为(14.3±2.1)d和(30.1±6.3)d,观察组平均起效时间和平均缓解时间与对照组比较差异有统计学意义(P<0.05);12个月内观察组和对照组患者再次出现新的骨转移瘤例数分别为14.29%(3/21)和28.57%(6/21),观察组少于对照组(P<0.05)。结论:三维适形放疗联合氯膦酸二钠治疗骨转移瘤疗效优于单纯放疗,具有较好的安全性。
Objective: To study the clinical effect of three-dimensional conformal radiotherapy combined with clodronate disodium on bone metastases. Methods: Forty-two patients with bone metastases treated by our hospital from August 2012 to April 2014 were selected and divided into observation group and control group according to the different treatment methods. In the observation group, 21 cases were treated with three-dimensional conformal radiotherapy combined with disodium clodronate, while 21 cases in the control group were treated with simple three-dimensional conformal radiotherapy. The effective rate was compared between the two groups. Results: The difference of pain relief rate between the observation group and the control group was statistically significant (P <0.05). The mean effective time and average relief time in the observation group were (8.0 ± 1.6) days and (25.1 ± 6.0) days respectively. The control group The average onset time and average relief time were (14.3 ± 2.1) d and (30.1 ± 6.3) days, respectively. The mean effective time and average relief time in the observation group were significantly different from those in the control group (P <0.05). 12 In the two months, the number of new bone metastases in observation group and control group was 14.29% (3/21) and 28.57% (6/21), respectively. The observation group was less than the control group (P <0.05). Conclusion: Three-dimensional conformal radiotherapy combined with clodronate disodium treatment of bone metastases is superior to radiotherapy alone, with good safety.