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恶性疟患者早期使用有效抗疟药可以迅速清除原虫血症,防止并发症从而降低死亡率。青蒿琥酯和其它青蒿素衍生物通过杀灭无性生殖阶段早期的环状体,达到有效地治疗急性无并发症的抗药性恶性疟。然而青蒿琥酯栓剂并不能减少复燃率;如继之口服甲氟喹却能杀灭剩余原虫,降低复燃发生率。 研究对象是曼谷医院1994年5月至7月入院诊断为恶性疟的30名年龄16周岁以上,体重超过45公斤的住院病人(不包括孕
Early use of effective antimalarial agents in patients with falciparum malaria can rapidly clear parasitemia and prevent complications that reduce mortality. Artesunate and other artemisinin derivatives are effective in the treatment of acute, uncomplicated, and resistant falciparum malaria by killing early rings in the asexual stage. Artesunate suppository, however, did not reduce the rate of relapse; if followed by oral mefloquine, it would kill the remaining protozoa and reduce the rate of relapse. The study population consisted of 30 hospitalized patients over the age of 16 with a body weight exceeding 45 kg admitted to Bangkok Hospital from May to July 1994 (excluding pregnancy