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目的 探讨不同剂量氯磷定和阿托品联合呼吸机治疗氧化乐果中毒所致呼吸肌麻痹的疗效。方法 所有实验大鼠均给予 2LD50 的氧化乐果染毒 ,并以 10mg/kg的阿托品有效对抗胆碱能症状。当大鼠出现呼吸频率减慢 ,呼吸困难征象时即行气管插管并辅助机械通气 (A组除外 ) ,B组阿托品继续原剂量治疗 ,C、D、E组氯磷定依次按 15、2 0、4 0mg/kg于呼吸机治疗即刻及治疗后 1、2、3h肌肉注射 ,阿托品减至首剂量的 1/3～ 2 /3,以维持阿托品化为度。经联合治疗后 1、2、3h试行脱机 ,若大鼠在上述时间中任何一次脱机 >6 0min ,则视为联合治疗成功。一次脱机后大鼠存活超过 6 0min或第 3次脱机后迅速死亡 ,均需取游离膈神经膈肌标本经MS 30 2生理药理分析仪作膈肌功能测定。结果 B组膈肌功能恢复不佳 ,无一只大鼠脱机成功 ;C组膈肌功能恢复良好 ,3h脱机成功率高达10 0 % ;D、E两组虽膈肌功能测定也较好 ,但脱机成功率极低。结论 只有适量氯磷定联合阿托品并辅助呼吸机治疗氧化乐果中毒所致的呼吸肌麻痹 ,才能加速中毒大鼠膈肌功能恢复 ,大大降低中毒大鼠病死率
Objective To investigate the efficacy of different doses of chlorpromazine and atropine combined with ventilator in the treatment of respiratory muscle paralysis caused by omethoate. Methods All experimental rats were administered 2LD50 of omethoate and were effective against the cholinergic symptoms with 10mg / kg atropine. In rats, respiratory rate was slowed down, signs of dyspnea when the endotracheal intubation and assisted mechanical ventilation (except group A), B group atropine continue the original dose of treatment, C, D, E group chloroprofen followed by 15,2 0 , 4 0mg / kg at the ventilator immediately and 1,2,3 h after treatment, intramuscular injection of atropine reduced to the first dose of 1/3 ~ 2/3, in order to maintain the degree of atropine. 1,2,3 after the joint trial off-line trial, if any time in the above-mentioned off-line> 60min, the combination therapy is considered successful. After an off-line survival of rats over 60min or the third after the death of the rapid death, are required to take phrenic diaphragm phrenic nerve samples by MS302 physiological and pharmacological analyzer for diaphragmatic function determination. Results In group B, the function of diaphragmatic muscle recovered poorly, and none of the rats were successfully off-line. The function of diaphragmatic muscle in group C recovered well and the success rate of off-line at 3 hours was as high as 10%. Although diaphragmatic function was also better in groups D and E, Machine success rate is very low. Conclusion Only moderate amount of chlorpromazine combined with atropine and assisted ventilator treatment of respiratory muscle paralysis caused by omethoate can accelerate the recovery of the diaphragm in rats with poisoning and greatly reduce the mortality of poisoned rats