GERD的基本治疗为中和食管反流酸和改善食管运动功能,其基本用药即为酸分泌抑制剂和消化道功能改善药。酸分泌抑制剂使用的同时,亦多联用制酸药、黏膜保护药。对于反流性食管炎的早期治疗,PPI比H2受体拮抗剂的治愈率和症状消除率效果显著。消化道功能改善药及酸分泌抑制剂仅用于症状缓解欠佳和疑及胃内容物排空延迟的情况。在非弥漫性胃食管反流病(NERD)的治疗上,宜以PPI开始,如效果不佳再改用安定药或消化道功能改善药等。 The basic treatment of GERD is to neutralize esophageal reflux acid and improve esophageal motor function, the basic drug is the acid secretion inhibitor and gastrointestinal function improvement drug. Acid secretion inhibitor at the same time, but also combined with antacids, mucosal protective drugs. For the early treatment of reflux esophagitis, PPI than H2 receptor antagonist cure rate and symptom elimination rate effect is significant. Gastrointestinal function improving drugs and acid secretion inhibitors are only used for poor symptom relief and suspicion of delayed gastric emptying. In non-diffuse gastroesophageal reflux disease (NERD) treatment should be started with PPI, such as ineffective and then switch to stability drugs or gastrointestinal function to improve drugs.