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组胺在体内分布广泛,有人认为定量测定尿中组胺的水平可间接指示机体释放情况,并可探讨其与疾病的关系。有人发现纽胺与休克、过敏、变态反应关系密切。也有人报道流行性脑膜炎严重时尿中组胺升高,恢复时尿中组胺也随之降低。关于急性心肌梗塞、心绞痛患者尿中组胺的变化如何,就已查阅的国内外文献未见有报道。前列腺素E_1(PGE_1)也广泛存在于人体许多脏器和组织细胞中,生物活性比较强。目前关于其对心血管作用的研究和综述,多认为PGE_1有扩张血管作用、抑制血小板聚集、调节免疫、抑制组胺释放等作用。近年来用PGE_1治疗末梢循环障碍有良好效果。本文介绍冠心病患者尿中组胺的变化及用我校研制的PGE_1在治疗中对组胺的影响。
Histamine is widely distributed in the body, some people think that quantitative determination of urinary histamine levels can indirectly indicate the release of the body, and to explore its relationship with the disease. Some people found that neuraminidase and shock, allergies, allergies are closely related. It was also reported in the epidemic of meningitis urinary histamine increased urinary histamine recovery also will be reduced. About acute myocardial infarction, angina patients with urinary histamine changes, have access to domestic and foreign literature have been seen no reports. Prostaglandin E_1 (PGE_1) is also widely present in many organs and tissues of the human body and has a high biological activity. Currently on its cardiovascular effects of research and review, and more that PGE_1 vasodilatation, inhibition of platelet aggregation, immune regulation, inhibition of histamine release and so on. In recent years, the treatment of peripheral circulation disorder with PGE_1 has a good effect. This article describes the changes of urinary histamine in patients with coronary heart disease and histamine effects in the treatment of PGE_1 developed by our school.