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由于抗氯喹恶性疟在西非地区的传播,从1986年至1989年,疟疾的发病率逐年上升,故需寻找其它有效药物来防治疟疾。作者在贝宁、加纳、几内亚、利比里亚、塞拉利昂和多哥无免疫力的人群中用甲氟喹进行了以下4个方面的观察:1.甲氟喹每隔2wk给药法的长期预防的效果;2.用此方法给药时测定甲氟喹的血浓度;3.估计抑制原虫血症所需的甲氟喹血浓度;4.评价长期服用甲氟喹的耐药性。志愿受试者须从4种化疗方法中选择一种:1.服甲氟喹250mg,每周1次,服4次后改为2wk1次;2.每周服盐酸氯喹基质300mg;3.每周服氯喹合并每天服盐酸氯胍
Because of the spread of chloroquine-resistant Plasmodium falciparum in West Africa, the incidence of malaria increased year by year from 1986 to 1989, so other effective drugs need to be found to combat malaria. The authors looked at mefloquine in four non-immunocompetent populations in Benin, Ghana, Guinea, Liberia, Sierra Leone and Togo in the following four areas: 1. Long-term prophylaxis of mefloquine every 2 weeks ; 2. determining the blood concentration of mefloquine when administered by this method; 3. estimating the mefloquine concentration required to inhibit parasitemia; 4. evaluating the long-term resistance to mefloquine. Volunteers to choose from four kinds of chemotherapy methods: 1. A mequofloxacin 250mg, once a week, after serving 4 times changed to 2wk1 times; 2. Weekly serving hydrochloride chloroquine 300mg; Weekly chlorophenolate hydrochloride daily service hydrochloride