论文部分内容阅读
本文报道辅Ｑ１０（ＣｏＱ１０）对超量ＡＡＰ引起小鼠急性肝损伤的保护作用。结果表明，预先给小鼠皮下注射ＣｏＱ１０，能对抗用量醋氨酚（ＡＡＰ）所致的肝糖原含量下降和肝损伤引起的ＳＡＬＴ活性升高及病理组织学变化；同时也发现ＣｏＱ１０。能使血清ＡＡＰ浓度和肝匀浆谷膦甘肽（ＧＳＨ）含量高于对照组。这说明ＣｏＱ１０对超量ＡＡＰ所致的急性肝损伤确有保护作用。从后三项实验结果来看，ＣｏＱ１０有间接稳定肝细胞膜的作用，使ＡＡＰ毒性中间代谢产物生成减少。
This article reports the protective effects of CoQ10 on acute liver injury induced by over-AAP in mice. The results showed that subcutaneously injecting CoQ10 into mice could counteract the decrease of hepatic glycogen content induced by acetaminophen (AAP) and the increase of SALT activity and histopathological changes induced by hepatic injury. CoQ10 also was found. Can make serum AAP concentration and liver homogenate glufosinate (GSH) content higher than the control group. This shows that CoQ10 does have a protective effect on acute liver injury caused by excessive AAP. From the latter three experimental results, CoQ10 has an indirect role in stabilizing the liver cell membrane, reducing the production of intermediate metabolites of AAP toxicity.