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目的探讨卡前列素氨丁三醇在前置胎盘中的应用。方法将前置胎盘患者100例作为治疗组,另选100例同期前置胎盘患者作为对照组(均排除凶险性前置胎盘)。两组均行腰硬联合麻醉下子宫下段剖宫产术。对照组术中胎儿娩出后即刻宫壁注射催产素20 IU,治疗组胎儿娩出后一次性宫体注射卡前列素氨丁三醇250μg,两组术后持续静脉滴注缩宫素20 IU维持6 h。观察两组手术中和手术后2 h、24 h内的出血情况和产后出血的发生率、产后24 h红细胞计数及Hb水平、产后血压的变化。结果与对照组比较,治疗组术后2 h、24 h内的出血量较少,产后出血的发生率较低(P值均<0.05);两组用药后血压的变化比较,差异无统计学意义(P>0.05);两组均无明显的不良反应。结论卡前列素氨丁三醇是预防前置胎盘产后出血的有效措施,值得推广应用。
Objective To investigate the application of carboprost trometamol in placenta previa. Methods One hundred patients with placenta previa as the treatment group and another 100 patients with the placenta previa as the control group (excluding dangerous placenta previa). Both groups underwent combined spinal and epidural anesthesia under the cesarean section. In the control group intraoperative intrauterine injection of oxytocin 20 IU immediately after intrauterine injection, a single intrauterine injection of carboprost tromethamine 250μg after the fetus was delivered in the treatment group, oxytocin 20 IU sustained intravenous infusion h The bleeding and the incidence of postpartum hemorrhage within 2 hours and 24 hours after operation and after operation were observed. The changes of erythrocyte count and Hb level and postpartum blood pressure at 24 h postpartum were observed. Results Compared with the control group, the bleeding volume within 2 h and 24 h after operation in the treatment group was less, and the incidence of postpartum hemorrhage was lower (P <0.05). There was no significant difference in blood pressure between the two groups Significance (P> 0.05); no significant adverse reactions in both groups. Conclusion Carprost trometamol is an effective measure to prevent postpartum hemorrhage in placenta previa, which is worth popularizing and applying.