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目的:系统评价西帕依固龈液治疗单纯性牙龈炎的临床疗效。方法:计算机检索CNKI中国知网(总库)(1979—2012)、维普期刊资源整合服务平台(1989—2013)、美国图书馆PubMed/MEDLINE相关文献。根据Jadad量表对纳入文献进行质量评价。采用Cochrane协作网提供的RevMan 5.2.0分析软件进行Meta分析。结果:共纳入6项临床随机对照研究,共490例单纯性牙龈炎患者。Meta分析结果显示,西帕依固龈液与安慰剂比较治疗单纯性牙龈炎龈沟出血指数(sulcus bleeding index,SBI)[WMD=-0.59,95%CI(-0.76,-0.42)]、菌斑指数(plaque index,PLI)[MD=-0.67,95%CI(-1.03,-0.30)];西帕依固龈液与西药比较治疗单纯性牙龈炎SBI[MD=-0.02,95%CI(-0.14,0.10)],PLI[MD=0.03,95%CI(-0.24,0.30)]。结论:西帕依固龈液治疗单纯性牙龈炎疗效优于安慰剂,与西药作用相似,可降低龈沟出血指数及菌斑指数,且无明显副作用,服用方便。由于纳入研究样本量小且质量较低,尚需开展高质量、多中心、大样本的临床随机双盲对照试验加以证实。
OBJECTIVE: To systematically evaluate the clinical efficacy of Xipayi gingival fluid in the treatment of simple gingivitis. Methods: The databases of CNKI (1979-2012), VIP Library Resources Integration Service Platform (1989-2013) and PubMed / MEDLINE Library of American Library were searched by computer. According to the Jadad scale, the quality of the included literature was evaluated. Meta-analysis was performed using RevMan 5.2.0 analysis software provided by the Cochrane Collaboration. Results: A total of 6 randomized controlled trials were included, 490 cases of simple gingivitis were included. Meta-analysis showed that sulcus bleeding index (SBI) [WMD = -0.59, 95% CI (-0.76, -0.42)] in the treatment of simple gingivitis compared with placebos The plaque index (PLI) [MD = -0.67,95% CI (-1.03, -0.30)] was higher in the treatment of simple gingivitis SBI compared with western medicine (MD = -0.02,95% CI (-0.14, 0.10)], PLI [MD = 0.03, 95% CI (-0.24, 0.30)]. CONCLUSION: Xipayilian gingival solution is superior to placebo in the treatment of simple gingivitis. Similar to Western medicine, it can reduce the bleeding index and plaque index of gingival sulcus and has no obvious side effects and is convenient for taking. Due to the small sample size and low quality of the included studies, high-quality, multicenter, large-scale clinical randomized double-blind controlled trials are needed.