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目的:对凹叶瑞香(Daphne retusa)的化学成分进行研究。方法:利用硅胶柱色谱,Sephadex LH-20和RP18反相柱色谱的方法分离和纯化化合物,通过光谱方法及理化性质鉴定化合物结构。结果:从凹叶瑞香氯仿部位分离得到8个香豆素类成分,分别为7-羟基香豆素(1),7-甲氧基-8-羟基香豆素(2),7-羟基-8-甲氧基香豆素(3),双白瑞香素-7-O-β-D-葡萄糖苷(4),伞形花内酯-7-O-β-D-葡萄糖苷(5),结香苷A和C(6和7),[8,8’-bi-2H-1-benzopyran]-2,2’-dione,7’-(α-D-glu-copyranosyloxy)-7-hydroxy-3-[(2-oxo-2H-1-benzopyran-7-yl)oxy](8)。结论:所有化合物均为首次从该植物中分得。
Objective: To study the chemical constituents of Daphne retusa. Methods: Compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and RP18 reversed-phase column chromatography. Their structures were identified by spectroscopic methods and physicochemical properties. Results: Eight coumarins were isolated from chloroform fractions of Euonymus japonicus, they were 7-hydroxycoumarin (1), 7-methoxy-8-hydroxycoumarin (2) Methoxy coumarin (3), bis-daphidin-7-O-β-D-glucoside (4), uveralone -7-O-β-D-glucoside (5) (6 and 7), [8,8’-bi-2H- 1 -benzopyran] -2,2’-dione, 7’- (α-D-glu-copyranosyloxy) hydroxy-3 - [(2-oxo-2H-1-benzopyran-7-yl) oxy] (8). Conclusion: All compounds were obtained from this plant for the first time.