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目的 对冠心病患者的血清微量元素进行分析，以期明确微量元素与冠心病的发生、发展的关系。方法 ５２例冠心病患者分为两组：①急性心肌梗死（ＡＭＩ）组２８ 例，②心绞痛（ＡＧ） 组２４ 例，并以３０ 例健康者作为对照组分别测定其血清锌（Ｚｎ）、铜（Ｃｕ）、铁（Ｆｅ） 、锰（Ｍｎ） 浓度。结果 ＡＧ组与ＡＭＩ组的血清Ｚｎ 值显著低于对照组（分别为０－７５ ±０－３８ μｇ／Ｌ，０－３１±０－１９ μｇ／Ｌ，１－０２±０－５３ μｇ／Ｌ，Ｐ均＜０－０１），ＡＭＩ组与ＡＧ 组Ｃｕ 值显著高于对照组（ 分别为１－４５±０－７９ μｇ／Ｌ，１－０９ ±０－６２ μｇ／Ｌ，０－７０±０－３９ μｇ／Ｌ，Ｐ均＜０－０１） 。结论 ①冠心病患者血清Ｚｎ 降低，我们推测机体为了减轻损害使Ｚｎ 的消耗增加有关。②冠心病患者血清Ｃｕ 升高，我们推测由于冠心病患者大量细胞缺血缺氧甚至坏死导致大量Ｃｕ 释放入血有关。
Objective To analyze the serum trace elements in patients with coronary heart disease so as to clarify the relationship between trace elements and the occurrence and development of coronary heart disease. Methods Fifty-two patients with coronary heart disease were divided into two groups: ① 28 cases of acute myocardial infarction (AMI), 24 cases of angina pectoris (AG) and 30 cases of healthy people as control group. The levels of serum zinc, (Cu), iron (Fe), manganese (Mn) concentration. Results Serum Zn in AG and AMI groups was significantly lower than that in control group (0-75 ± 0-38 μg / L, 0-31 ± 0-19 μg / L, 1-02 ± 0-53 μg / L , P <0-01). The Cu values in AMI group and AG group were significantly higher than those in control group (1-45 ± 0-79 μg / L, 1-09 ± 0-62 μg / L, 0-70 ± 0-39 μg / L, all P <0-01). Conclusion ① serum Zn in patients with coronary heart disease decreased, we speculate that the body in order to reduce damage to increase the consumption of Zn. ② coronary heart disease patients with elevated serum Cu, we speculate that due to a large number of patients with coronary heart disease caused by a large number of cellular ischemia and hypoxia or necrosis necrosis related to the release of blood.