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宫内病毒感染尤其是巨细胞病毒（ＣＭＶ）感染是致畸的重要原因之一，为了解我市畸形儿病毒感染的状况，探讨ＣＭＶ在致畸上的作用及相关性，本室从汕头市各医院收集了２４例畸形儿（无脑儿、脊柱裂、异位心、多发性畸形、巨大肝等），取母、婴配对标本（包括羊水、母血、宫颈分泌物、乳汁及畸形儿心血、咽拭子）共１２８份进行常规病毒分离、鉴定，并用ＥＬＩＳＡ法测定母、婴血清中抗ＣＭＶ、ＩｇＧ、ＩｇＭ抗体。结果从２４例畸形儿中分离到ＣＭＶ１例，ＨＳＶ－２型１例，检出ＣＭＶ－ＩｇＭ３例（其中１例为ＣＭＶ分离阳性），病毒检测阳性率为１６．６７％（４／２４），而ＣＭＶ占病毒感染的３／４，初步结果提示本市畸形儿病毒感染因素不容忽视，而在病毒感染中以ＣＭＶ为主要病原。
Intrauterine virus infection, especially cytomegalovirus (CMV) infection is one of the important causes of teratogenicity. To understand the status of mycoplasma virus infection in our city and to explore the role of the CMV in the teratogenicity and the relevance of this room from Shantou The hospital collected 24 cases of deformed children (no brain children, spina bifida, ectopic heart, multiple deformities, huge liver, etc.), take maternal and infant pairs of specimens (including amniotic fluid, maternal blood, cervical secretions, milk and deformed children Blood, throat swab) 128 routine virus isolation and identification, and determination of anti-CMV, IgG, IgM antibodies in serum of maternal and infant by ELISA. Results One case of CMV was isolated from 24 cases of deformity and one case of HSV-2. CMV-IgM was detected in 3 cases (1 case was CMV positive). The positive rate of virus detection was 16.67% (4/24) The CMV accounted for 3/4 of the virus infection, the preliminary results suggest that the city of deformed children virus infection can not be ignored, but in the virus infection with CMV as the main pathogen.