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目的 1.探讨急性肾功能衰竭(ARF)时肾实质背向散射积分(IBS)的变化情况。2.探讨ARF时肾实质IBS改变与病理改变的关系;3.分析ARF时肾实质IBS改变与超声其它参数的相关性。 资料与方法 日本大耳白兔20只,体重2100～2300g,兔后腿肌注50％的甘油12～15ml/kg,建立急性肾小管坏死性ARF动物模型,分别于注药前(T_0)、注药后1、3、5…13天(T_1…T_(13))共8个时间点行超声检查,超声检查后沿兔耳缘静脉抽血1毫升测定血Cr、BUN,在每个时间点处死1只兔子,并取出肾脏送病理检查,经血Cr、BUN及病理检查所有兔子均于给药1～3天内发生了不同程度的ARF。使用HP 5500超声诊断仪,探头频率3～6MHz和3～8MHz,检查中仪器设置
Objective 1. To investigate the changes of renal parenchymal backscatter (IBS) in patients with acute renal failure (ARF). To investigate the relationship between renal IBS changes and pathological changes in ARF.3. To analyze the correlation between renal IBS changes and other parameters of ultrasound during ARF. Materials and Methods Twenty rabbits were randomly divided into control group (n = 20), weight of 2100 ~ 2300g, rabbit intramuscular injection of 50% glycerin 12 ~ 15ml / kg, acute renal tubular necrosis ARF animal model were established, At 1, 3, 5 ... 13 days after injection (T_1 ... T_ (13)), ultrasound examination was performed at 8 time points. Blood samples were collected for blood Cr, One rabbit was sacrificed and the kidneys were removed for pathological examination. All rabbits in the blood samples were examined for Cr, BUN and pathology. ARF occurred in varying degrees in 1-3 days. Use HP 5500 ultrasonic diagnostic apparatus, the probe frequency 3 ~ 6MHz and 3 ~ 8MHz, check the instrument settings