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动脉粥样硬化(AS)不仅是一种炎症性疾病,而且属于一种代谢性疾病。肠道微生态的改变可对AS的发生发展产生双面影响。一方面,肠道菌群紊乱可以通过影响机体的胆碱代谢、氧化应激、炎症反应等机制直接促进AS产生发展,此外,可通过导致AS危险因素肥胖、高脂血症、糖尿病等的产生这些间接机制促AS的进展。另一方面,益生菌及益生元的增加则可有效地降低肠道微生物内毒素产生、增强肠道屏障、减轻机体质量、缓解炎症反应、改善胰岛素抵抗,进而在AS的进展方面发挥重要作用。因此,合理调控机体肠道微生态环境成为AS防治的新型重要手段。
Atherosclerosis (AS) is not only an inflammatory disease, but also a metabolic disease. Intestinal microflora changes can have a double-sided impact on the occurrence and development of AS. On the one hand, intestinal flora disruption can directly affect the development of AS by affecting the body’s mechanisms of choline metabolism, oxidative stress and inflammatory reaction. In addition, through the production of AS risk factors such as obesity, hyperlipidemia and diabetes These indirect mechanisms promote the progress of AS. On the other hand, the increase of probiotics and prebiotics can effectively reduce intestinal microbial endotoxin production, enhance intestinal barrier, reduce body mass, relieve inflammation and improve insulin resistance, and play an important role in the progression of AS. Therefore, a reasonable regulation of intestinal micro-ecological environment has become a new AS prevention and control important means.