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目的探讨分析益生菌联合谷氨酰胺的肠内营养对重症急性胰腺炎肠黏膜屏障恢复的作用.方法 选取2014-8-2015-8期间在我院收治的52例重症急性胰腺炎患者,将其随机分为实验组和对照组,实验组给予益生菌联合谷氨酰胺的肠内营养,对照组给予常规肠内营养,比较两组患者治疗第1、7、14、21d时的APACHEII评分及血浆DAO、DG乳酸、内毒素、TNFGα水平情况.结果 在第14d观察组患者的APACHEII评分明显低于对照组,P<005,差异具有统计学意义.治疗第1、7d两组患者的血浆DAO、DG乳酸、内毒素、TNFGα水平无明显差异,P>005,差异无统计学意义;第14、21d两组患者血浆DAO、DG乳酸、内毒素、TNFGα水平差异明显,P<005,差异具有统计学意义.结论 益生菌联合谷氨酰胺的肠内营养能够更好地保护重症急性胰腺炎肠道黏膜屏障的完整,可促进患者肠黏膜屏障功能的恢复.
Objective To investigate the effect of probiotics combined with glutamine enteral nutrition on the recovery of intestinal mucosal barrier in patients with severe acute pancreatitis.Methods Fifty-two patients with severe acute pancreatitis treated in our hospital from August 2014 to May 2015 were enrolled, Randomly divided into experimental group and control group, the experimental group was given probiotics combined with glutamine enteral nutrition, the control group was given routine enteral nutrition, compared the two groups of patients on the first 1,7,14,21 d APACHEII score and plasma DAO, DG lactic acid, endotoxin and TNFα.Results On the 14th day, the APACHEII score of the observation group was significantly lower than that of the control group, P <005, the difference was statistically significant.At the first day and the 17th day, the plasma DAO, DG lactic acid, endotoxin, TNFGα levels no significant difference, P> 005, the difference was not statistically significant; 14th and 21st day plasma DAO, DG lactic acid, endotoxin, TNFGα levels were significantly different, P <005, the difference was statistically significant Significance.Conclusion Probiotics combined with glutamine enteral nutrition can better protect the integrity of intestinal mucosal barrier in patients with severe acute pancreatitis and promote the recovery of intestinal mucosal barrier function.