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目的 :观察拉米夫定治疗慢性乙型肝炎伴AFP增高的临床疗效。方法 :口服拉米夫定 10 0mg/天 ,6个月后进行第一阶段评定 ,接连第二阶段仍以拉米夫定攻固。结果 :8例病人经 6个月治疗后HBV -DNA全转阴 ,AFP、ALT随HBV -DNA阴转而逐渐恢复正常。但是第二阶段治疗时有 2例HBV -DNA复阳 ,其中一例YMDD变异。结论 :拉米夫定治疗慢性乙型肝炎1伴AFP增高疗效显著 ,但是用药时间不宜过长 ,长期服用会出现病毒耐药和变异。
Objective: To observe the clinical efficacy of lamivudine in the treatment of chronic hepatitis B with AFP. Methods: Lamivudine orally 10mg / day, 6 months after the first phase of assessment, followed by the second phase is still lamivudine tapping. Results: HBV-DNA was completely negative in 8 patients after treatment for 6 months. AFP and ALT gradually returned to normal with HBV-DNA negative conversion. However, during the second phase of treatment, there were 2 HBV-DNA complex positive cases, of which one case of YMDD mutation. Conclusion: Lamivudine treatment of chronic hepatitis B with AFP increased significantly effect, but the medication should not be too long, long-term use will appear virus resistance and mutation.