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目的探讨二甲双胍、吡格列酮联合用药与单独用药治疗非酒精性脂肪性肝病(NAFLD)的疗效。方法将120例NAFLD患者随机分成对照组、二甲双胍组、吡格列酮组、联合治疗组,每组各30例。对照组不采用任何药物治疗;二甲双胍组采用二甲双胍治疗;吡格列酮组采用吡格列酮治疗;联合治疗组采用二甲双胍、吡格列酮联合治疗,比较各组的临床疗效。结果所有药物治疗组的各项指标与治疗前比较均明显改善(P<0.05)。联合治疗组的总有效率为96.7%,明显高于二甲双胍组的80%和吡格列酮组的76.7%(P<0.05);3个药物治疗组的治疗,总有效率均明显高于对照组(P<0.05)。结论二甲双胍、吡格列酮在NAFLD的治疗中具有一定的疗效,二者联合用药治疗的临床疗效更为显著。
Objective To investigate the efficacy of combination of metformin and pioglitazone in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods A total of 120 NAFLD patients were randomly divided into control group, metformin group and pioglitazone group, and 30 patients in each group. The patients in the control group were treated with metformin, the patients in the metformin group were treated with metformin, the patients in the pioglitazone group were treated with pioglitazone, and the patients in the combination therapy group were treated with metformin and pioglitazone. The clinical efficacy of each group was compared. Results The indexes of all the drug treatment groups were significantly improved compared with those before treatment (P <0.05). The total effective rate was 96.7% in the combined treatment group, which was significantly higher than that in the metformin group and 76.7% in the pioglitazone group (P <0.05). The treatment and total effective rates in the three drug treatment groups were significantly higher than those in the control group <0.05). Conclusions Metformin and pioglitazone have certain curative effect in the treatment of NAFLD, and the combination curative effect of the two drugs is more obvious.