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目的 探讨癌基因蛋白表达在骨巨细胞瘤生物学行为与预后方面的意义。方法 对 46例骨巨细胞瘤 (含 10例肿瘤复发 )进行Jaffe分级与综合分级 ;同时镜下确认有否侵袭周围组织与出血坏死 ,结合免疫组织化学技术检测Ki6 7,bcl 2 ,c erbB 2及nm2 3 4种癌基因蛋白表达。结果 在肿瘤的出血坏死、侵袭与复发方面 ,Ⅰ、Ⅱ、Ⅲ级之间的差异无显著性 ,Ⅲ级分类与综合分级也无相关性。 4种癌基因产物的表达在一定程度上与其侵袭复发有关。结论 单纯Ⅲ级分类法在反映骨巨细胞瘤的生物学行为方面存在着一定的局限性。癌基因产物的表达参照综合分级可能成为推断骨巨细胞瘤的性质与预后重要参考指标。
Objective To investigate the significance of oncogene protein expression in the biological behavior and prognosis of giant cell tumor of bone. Methods 46 cases of giant cell tumor of bone (including 10 cases of tumor recurrence) were treated with Jaffe classification and comprehensive grading. At the same time, it was confirmed by microscope whether there was invasion of peripheral tissue and hemorrhagic necrosis. Ki6 7, bcl 2 and c erbB 2 were detected by immunohistochemistry And nm2334 oncogene protein expression. Results There was no significant difference in grade Ⅰ, Ⅱ, and Ⅲ between hemorrhage, necrosis, invasion and recurrence of tumor. No correlation was found between grade Ⅲ and comprehensive classification. The expression of four oncogenes was related to the invasion and recurrence to a certain extent. Conclusion The simple grade Ⅲ classification has some limitations in reflecting the biological behavior of giant cell tumor of bone. Reference to the comprehensive classification of oncogene product expression may be an important reference for determining the nature and prognosis of giant cell tumor of bone.