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目的 分析根治性近端胃切除空肠间置吻合术与根治性全胃切除食管空肠Roux-en-Y吻合术对胃癌病人术后恢复及生活质量的影响.方法 近端胃癌病人50例,按数字表法将50例病人随机分为对照组和观察组,每组25例.对照组病人实施根治性全胃切除食管空肠Roux-en-Y吻合术,观察组病人实施根治性近端胃切除空肠间置吻合术.比较两组病人手术前后血常规、肝肾功能、术后并发症发生情况、术后胃食管反流情况以及手术前后生活质量.结果 两组病人术前、术后血常规和肝肾功能各项指标无明显变化,差异无统计学意义(P>0.05).观察组术后出现反流性食管炎明显少于对照组,钡剂反流入食管例数明显少于对照组,差异有统计学意义(P<0.05).两组病人术后躯体功能、情绪功能、整体健康生活质量评分和术前比较明显较高,观察组病人术后情绪功能、整体健康生活质量评分和对照组比较明显较高,差异有统计学意义(P0.05).The incidence of postoperative reflux esophagitis in the observa-tion group was significantly less than that in the control group,and the number of cases with barium reflux into the esophagus in the observation group was significantly less than that in the control group,and the differences were statistically significant(P<0.05).The physical function score,emotional function score and overall health quality of life score of patients in two group after surgery were significantly higher than those in two groups before surgery,and the emotion function score and overall health quality of life score of patients in two groups after surgery were significantly higher than those before surgery,and the differences were statistically significant(P<0.05).Conclusion Radical proximal gastrectomy jejunal interposition anastomosis can significantly reduce the incidence of postoperative reflux esophagitis in patients with gas-tric cancer,and can significantly improve the quality of life of patients,and the clinical effect is better than radical total gastrectomy esophageal Roux-en-Y anastomosis.