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临床研究显示血清三酰甘油水平的增高与动脉粥样硬化疾病的发生密切相关,并独立于血清高密度脂蛋白和低密度脂蛋白。在所有富含三酰甘油的脂蛋白中,残余脂蛋白已经被认为具有较强的致动脉粥样硬化作用,是冠状动脉疾病的独立危险因素。机制研究显示,残余脂蛋白通过诱导血管平滑肌细胞的增殖,引起内皮细胞功能失调并诱导其凋亡,促进炎症的发生及影响其他脂蛋白的代谢等一系列复杂的病理生理学过程导致动脉粥样硬化。因此,理论上降低残余脂蛋白的水平,抑制其代谢过程,可以控制动脉粥样硬化的发生。
Clinical studies have shown that elevated serum triglyceride levels and atherosclerotic disease are closely related, and independent of serum high-density lipoprotein and low-density lipoprotein. Of all triglyceride-rich lipoproteins, residual lipoproteins have been identified as having a strong atherogenic effect and are independent risk factors for coronary artery disease. Mechanism studies show that residual lipoproteins induce atherosclerosis through a series of complex pathophysiological processes such as inducing vascular smooth muscle cell proliferation, causing endothelial dysfunction and inducing apoptosis, promoting inflammation, and affecting the metabolism of other lipoproteins . Therefore, theoretically reduce the level of residual lipoprotein, inhibit the metabolic process, can control the occurrence of atherosclerosis.