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目的 :探讨横纹肌肉瘤的诊断和鉴别诊断中免疫组织化学标记的意义及不同类型横纹肌肉瘤对预后的影响。方法 :应用病理形态学和免疫组化方法对 47例横纹肌肉瘤进行研究。结果 :47例横纹肌肉瘤中胚胎性 2 8例 ,腺泡状 16例 ,其中 7例伴广泛侵润、复发和转移 ,多型性 3例 ;结蛋白 (desm in)和肌球蛋白 (m yoglobin)的阳性率分别为 (89% )和 (83.2 % )。结论 和胚胎性横纹肌肉瘤相比 ,腺泡状横纹肌肉瘤具有更恶的临床生物学行为 ;desm in和myoglobin是横纹肌肉瘤较为理想的免疫组化标记
Objective: To explore the significance of immunohistochemical markers in the diagnosis and differential diagnosis of rhabdomyosarcoma and the effect of different types of rhabdomyosarcoma on prognosis. METHODS: Forty-seven cases of rhabdomyosarcoma were studied by histopathology and immunohistochemistry. RESULTS: Of the 47 cases of rhabdomyosarcoma, 28 were embryonal and 16 were alveolar, of which 7 were associated with extensive invasion, recurrence, and metastasis, and 3 were polymorphic; desmin and myosin The positive rates were (89%) and (83.2%), respectively. Conclusion Compared with embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma has worse clinical biological behavior; Desmin and myoglobin are ideal immunohistochemical markers for rhabdomyosarcoma.