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目的 研究米帕明和丁螺环酮对小鼠探究行为、自主活动以及隔离攻击行为的影响。方法 雄性昆明种小白鼠隔离饲养 38～ 45天 ,建立隔离小鼠攻击模型。急性腹腔注射生理盐水或米帕明或丁螺环酮 ,30min后测定小鼠的攻击行为。采用XZC 4A自主活动测定仪 ,测定群居小鼠的探究行为和自主活动性。结果 (1)米帕明各剂量组 (0mg/kg ,2 5mg/kg ,5 0mg/kg ,10 0mg/kg)攻击行为的潜伏期 ( x±s)分别为 (5 2± 2 8)s ,(6 7± 47)s ,(132± 87)s ,(2 2 8± 94)s;呈剂量依赖性延长隔离小鼠攻击行为的潜伏期 ,拮抗其攻击行为。然而 ,同等剂量的米帕明对群居小鼠的自主活动和探究行为无明显影响。 (2 )丁螺环酮 2 5mg/kg,5 0mg/kg ,10 0mg/kg剂量组的攻击行为潜伏期 ( x±s)分别为(2 15± 74)s,(134± 10 3)s和 (30 0± 0 )s。与生理盐水组 (18± 7)s相比较 ,差异有显著性 (P <0 0 5 ) ,可明显抑制隔离小鼠的攻击行为。给小鼠腹腔注射相同剂量丁螺环酮 ,呈剂量依赖性减少群居小鼠的自主活动和探究行为。结论 米帕明和丁螺环酮均具有抗隔离小鼠攻击行为的药理活性。
Objective To study the effects of paclitaxel and buspirone on inquiry behavior, autonomic activity and isolation attack in mice. Methods Male Kunming mice were isolated and kept for 38-45 days to establish an isolated mouse model. Acute intraperitoneal injection of normal saline or mipamin or buspirone, 30 min after the mice were tested for aggressive behavior. Using XZC 4A autonomic activity detector to detect the behavior of the study and social mobility of social mice. Results (1) The latency (x ± s) of each dose of paclitaxel (5mg / kg, 25mg / kg, 50mg / kg and 100mg / kg) (6 7 ± 47) s, (132 ± 87) s, (2 2 8 ± 94) s, respectively. The latency of challenge mice was prolonged in a dose-dependent manner to antagonize their aggressive behavior. However, the same dose of Mycophenamido had no significant effect on spontaneous activity and exploration behavior in the mice. (2) The incubation period (x ± s) of buspirone 25 mg / kg, 50 mg / kg and 100 mg / kg were (2 15 ± 74) s and (30 0 ± 0) s. Compared with saline group (18 ± 7) s, the difference was significant (P <0 05), which could obviously inhibit the attack behavior of isolated mice. The mice were injected intraperitoneally with the same dose of buspirone, in a dose-dependent manner to reduce the autonomous mice and explore behavior. Conclusion Both paclitaxel and buspirone possess pharmacological activity against challenge in isolated mice.