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目的 探讨IL-18在原发性高血压危象中改变的临床意义。方法 采用酶联免疫分析法(ELISA)动态检测 40例原发性高血压危象患者和30例健康对照者血清IL-18的含量,并用简单相关分析血清IL-18的含量变化与血压的相关性。结果 原发性高血压危象患者血清IL-18的含量显著高于健康对照组(191.34±56.28ng/L vs 64.81±14.33ng/L,P<0.01);治疗后12h后患者血清IL-18的含量则明显下降(191.34±56.28ng/L vs 144.63±54.33ng/L,P<0.05),但仍显著高于对照组(144.63±54.33ng/L vs 64.81±14.33ng/L,P<0.01);治疗3d后病人的血清IL-18的含量则基本恢复致正常水平,与对照组比较则无显著性差异(81.67±37.53ng/L vs 64.81±14.33ng/L,P>0.05)。且危象期患者的血清IL-18的含量与收缩压呈明显的正相关性(r=0.48,P<0.05),但与舒张压之间则无明显的相关性(r=0.24,P>0.05)。血清IL-18的含量随高血压患者的病情危重而升高,血压下降而下降,且与其收缩血压呈明显的正相关性。结论 高血压患者存在免疫功能紊乱,IL-18可能参与了原发性高血压危象的发病机制,检测患者的血清IL-18的含量可能有助于判断患者的病情变化和预后效果。
Objective To investigate the clinical significance of IL-18 in the crisis of essential hypertension. Methods Serum levels of IL-18 in 40 patients with essential hypertension and 30 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA). Correlation between serum IL-18 levels and blood pressure was analyzed by simple correlation analysis Sex. Results The levels of serum IL-18 in patients with essential hypertension were significantly higher than those in healthy controls (191.34 ± 56.28ng / L vs 64.81 ± 14.33ng / L, P <0.01). Serum levels of IL-18 (191.34 ± 56.28ng / L vs 144.63 ± 54.33ng / L, P <0.05), but still significantly higher than the control group (144.63 ± 54.33ng / L vs 64.81 ± 14.33ng / L, P <0.01) ). The level of serum IL-18 in patients after 3 days of treatment was basically normal, which was not significantly different from the control group (81.67 ± 37.53ng / L vs 64.81 ± 14.33ng / L, P> 0.05). Serum IL-18 levels in crisis-related patients were positively correlated with systolic blood pressure (r = 0.48, P <0.05), but not with diastolic blood pressure (r = 0.24, P> 0.05). Serum IL-18 levels with the severity of patients with hypertension increased, blood pressure decreased and decreased, and its systolic blood pressure was significantly positively correlated. Conclusions There are immune dysfunction in patients with hypertension. IL-18 may be involved in the pathogenesis of essential hypertension crisis. Detecting serum IL-18 level may be helpful in judging the patient’s condition and prognosis.