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应用放射免疫分析法,检测63例肺癌患者血浆ET-1含量,并观察了31例患者手术前后的含量变化。结果显示,肺癌患者血浆ET-1的含量明显高于正常对照组(P<0.01);手术后患者血浆ET-1含量较手术前有不同程度的下降,手术前、后相比较有显著性差异(P<0.05)。提示,血浆ET-1含量测定对肺癌的辅助诊断及监测病情轻重、手术效果和预后有一定的临床意义。
Radioimmunoassay was used to detect plasma ET-1 levels in 63 patients with lung cancer, and 31 patients were observed before and after surgery. The results showed that the plasma ET-1 content was significantly higher in lung cancer patients than in the normal control group (P<0.01); the plasma ET-1 levels after surgery decreased to varying degrees before surgery, and there was a significant difference before and after surgery. (P<0.05). It is suggested that the determination of plasma ET-1 level has certain clinical significance in the diagnosis of lung cancer, the severity of the disease, the effect of surgery, and the prognosis.