p53是研究较为广泛的抑癌基因,随着p53的广泛和深入研究,其家族成员p63与p73陆续被发现后,即成为人们关注的热点。本文就p63、p73的表达类型、结构和功能及其与头颈部肿瘤的相关性作一综述。 p53 is a widely studied tumor suppressor gene. With extensive and in-depth study of p53, its family members p63 and p73 have been discovered one after another, which has become a hot spot for people’s attention. This review summarizes the expression types, structures and functions of p63 and p73 and their relationship with head and neck tumors.