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目的研究50岁以下冠心病患者危险因素,对高危中青年人的冠心病一级预防提供参考。方法根据156例冠状动脉造影结果将50岁以下行冠脉造影者分为冠心病组(89例)和非冠心病组(67例),收集临床心血管危险因素资料进行Logistic多因素回归分析。结果156例冠状动脉造影者中89例诊断为冠心病(57.1%),67例无冠心病(42.9%)。Logistic多因素回归分析显著冠心病家族史、血浆总胆固醇水平及吸烟为冠心病的独立危险因素,其相关系数分别为0.63、0.50、0.97,优势比(OR)分别为1.06、1.65、2.64(P<0.05)。结论冠心病家族史、血浆总胆固醇水平高及吸烟是中青年人冠心病发生的高危因素,对这类人群应尽早干预。
Objective To study the risk factors of coronary heart disease (CHD) in patients under 50 years of age and provide reference for primary prevention of CHD in high-risk young adults. Methods According to the results of coronary angiography in 156 cases, coronary angiography under 50 years old was divided into coronary heart disease group (n = 89) and non-coronary heart disease group (67 cases). Data of clinical cardiovascular risk factors were collected for Logistic regression analysis. Results Among the 156 cases of coronary angiography, 89 cases were diagnosed as coronary heart disease (57.1%) and 67 cases were coronary heart disease (42.9%). Logistic multivariate regression analysis revealed significant family history of coronary heart disease, total cholesterol levels and smoking as independent risk factors for coronary heart disease. The correlation coefficients were 0.63,0.50,0.97 and odds ratios (OR) were 1.06,1.65,2.64 (P <0.05). Conclusions The family history of coronary heart disease, high plasma total cholesterol and smoking are risk factors of coronary heart disease in young people. Intervention should be done as early as possible for these people.