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报告成人中枢神经系统白血病(CNSL)151例,结果表明:CNSL与白血病的细胞类型、患者年龄、存活期及治疗方法有关。在急性淋巴细胞性白血病和急性非淋巴细胞白血病中,存活期<1年时,CNSL的发生率以前者为高,存活期>1年时,两者无显著性差异(x2=0.35,P>0.05)。该组有57例(37.7%)CNSL缓解后出现复发,说明目前的治疗方法仍难阻止CNSL的出现和复发。比较鞘内化疗加局部放疗和仅用鞘内化疗的疗效,两者无显著性差异(r=0.02,P>0.05)。
Reported 151 cases of adult central nervous system leukemia (CNSL). The results show that: CNSL is related to leukemia cell type, patient age, survival and treatment methods. In acute lymphoblastic leukemia and acute non-lymphocytic leukemia, the incidence of CNSL was higher in the survival period <1 year, and there was no significant difference in survival between the two groups (x2=0.35). P>0.05). In this group, 57 (37.7%) CNSLs relapsed after remission, indicating that the current treatment methods are still difficult to prevent the emergence and recurrence of CNSL. Compared with intrathecal chemotherapy plus local radiotherapy and intrathecal chemotherapy alone, there was no significant difference (r=0.02, P>0.05).