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目的探讨慢性阻塞性肺疾病(COPD)合并抑郁患者与呼吸衰竭、肺性脑病发生的关系。方法随机选取2009年10月-2011年10月住院期间COPD患者共92例,行抑郁自评量表及汉密尔顿抑郁量表测评,记录住院期间血气分析结果。结果汉密尔顿抑郁量表研究计算入选92例患者中合并抑郁患者53例,抑郁发病率57.6%,其中37例(69.8%)为中重度抑郁。COPD抑郁患者合并呼吸衰竭者33例,合并肺性脑病表现24例。呼吸衰竭、肺性脑病的发生率与COPD患者抑郁状态有关,合并抑郁状态的COPD患者发生呼吸衰竭的可能性是单纯COPD患者的2.5倍,发生肺性脑病的可能性是单纯COPD患者的1.7倍。结论 COPD合并抑郁患者较单纯COPD患者易发生呼吸衰竭及肺性脑病,肺性脑病产生的神经精神异常进一步加重抑郁情绪。
Objective To investigate the relationship between chronic obstructive pulmonary disease (COPD) and depression in patients with respiratory failure and pulmonary encephalopathy. Methods A total of 92 patients with COPD during hospitalization from October 2009 to October 2011 were randomly selected and evaluated by Depression Scale and Hamilton Depression Scale. The blood gas analysis results during hospitalization were recorded. Results The Hamilton Depression Scale Study calculated 53 patients with depression in 92 patients, the incidence of depression was 57.6%, of which 37 (69.8%) were moderate to severe depression. 33 cases of COPD patients with respiratory failure and 24 cases of pulmonary encephalopathy. Respiratory failure, pulmonary encephalopathy and COPD patients with the incidence of depression related to COPD patients with depression, the possibility of respiratory failure was 2.5 times that of patients with COPD alone, the possibility of pulmonary encephalopathy was 1.7 times that of patients with COPD alone . Conclusions Patients with COPD complicated with depression are more likely to develop respiratory failure and pulmonary encephalopathy than those with simple COPD. The neuropsychiatric disorders caused by pulmonary encephalopathy further aggravate the depression.