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1例63岁男性患者因尿急、尿痛，自行口服盐酸坦索罗辛缓释胶囊（0.2 mg、1次/d）和前列欣胶囊（2 g、3次/d）。服药25 d后，出现皮肤瘙痒、深茶色尿、恶心、乏力、食欲下降，实验室检查示丙氨酸转氨酶（ALT）265 U/L，天冬氨酸转氨酶（AST）163 U/L，总胆红素（TBil）155.1 μmol/L，直接胆红素（DBil）74.7 μmol/L，间接胆红素（IBil）80.4 μmol/L，碱性磷酸酶（ALP）261 U/L，γ-谷氨酰转移酶（γ-GT）184 U/L。肝穿刺结果提示胆汁淤积型肝损伤。诊断：急性药物性肝损伤，可能与上述2药有关。停用上述2药，口服熊去氧胆酸250 mg、3次/d。停药42 d复查结果示ALT 368 U/L，AST 179 U/L，TBil 504.9 μmol/L，DBil 382.8 μmol/L，IBil 122.1 μmol/L，ALP 201 U/L，γ-GT 58 U/L。停药91d：ALT 78 U/L，AST 62 U/L，TBil 138.1 μmol/L，DBil 118.2 μmol/L，IBil 20.2 μmol/L，ALP 140 U/L，γ-GT 31 U/L。停药135 d肝功能恢复正常。“,”A 63-year-old male patient took tamsulosin hydrochloride sustained release capsules 0.2 mg daily and n Qianliexin capsules 2 g thrice daily by himself for urinary urgency and urodynia. Twenty-five days later, he developed itchy skin, deep brown urine, nausea, fatigue, and loss of appetite. Laboratory tests showed alanine aminotransferase (ALT) 265 U/L, aspartate aminotransferase (AST) 163 U/L, total bilirubin (TBil) 155.1 μmol/L, direct bilirubin (DBil) 74.7 μmol/L, indirect bilirubin (IBil) 80.4 μmol/L, alkaline phosphatase (ALP) 261 U/L, and gamma-glutamyltransferase (γ-GT) 184 U/L. Liver biopsy showed the cholestatic liver injury. He was diagnosed as acute drug-induced liver injury, which might be related to the above 2 drugs. The above 2 drugs were stopped and oral ursodeoxycholic acid 250 mg thrice daily was given. On day 42 of drug withdrawal, laboratory tests showed ALT 368 U/L, AST 179 U/L,TBil 504.9 μmol/L, DBil 382.8 μmol/L, IBil 122.1 μmol/L, ALP 201 U/L, and γ-GT 58 U/L. On day 91 of drug withdrawal, laboratory tests showed ALT 78 U/L, AST 62 U/L, TBil 138.1 μmol/L, DBil 118.2 μmol/L, IBil 20.2 μmol/L, ALP 140 U/L, and γ-GT 31 U/L. The patient′s liver function returned to normal 135 days after drug withdrawal.n