论文部分内容阅读
多药耐药现象（ＭＤＲ）是恶性肿瘤难以治愈的重要原因之一。目前对ＭＤＲ现象机制的研究主要集中在多药耐药基因ｍｄｒ１及其表达产的 Ｐ糖蛋白（Ｐ－ｇｌｙｃｏｐｒｏｔｅｉｎ，Ｐｇｐ）、ＤＮＡ拓扑异构酶Ｈ（Ｔｏｐｏ Ⅱ）、谷胱甘肽流转移酶（ＧＳＹ）、多药耐药相关蛋白
The phenomenon of multidrug resistance (MDR) is one of the important reasons for the difficult cure of malignant tumors. The current research on the mechanism of MDR mainly focuses on the multidrug resistance gene mdr1 and its expressed P-glycoprotein (Pgp), DNA topoisomerase H (Topo II), and glutathione flow transferase. (GSY), Multidrug Resistance Associated Protein