The Ekomedion two-mica granite,southwest Cameroon,has potential for uranium and molybdenum mineralization.Here,we present LA-ICP-MS U-Pb ages,Lu-Hf isotope characteristics,trace element concentrations and Ti-geothermometry of zircon from this granite hosting U-Mo mineralization in pegmatitic pods.The majority of zircon are CL-dark though some CL-bright cores were also identified.U-Pb zircon age data range from 121 ± 3 to 743 ± 11 Ma with only 5 of 34 ages being near concordant.The concordant mean age of 603 ± 12 Ma is similar to ages of granitic intrusions along the Central African Shear Zone in Cameroon.Apparent ages with mean of 261 ± 6 Ma reveal open system behavior with respect to Pb and/or U.Zircon εHfi values range from-20.3 to -0.3.This implies that U-Mo was remobilized during partial melting of the surrounding gneiss.Zircon Th/U ＞ 0.1 as well as an increasing Hf with decreasing Th/U indicates that fractional crystallization was the main factor that controlled U-Mo mineralization in pegmatitic pods.Y and Y/Ho ratios cluster from 29 to 33 close to the chondritic ratio of 28 and indicate fractionation of Y and Ho with low F contents during the earliest stages of crystallization.Late stage accumulation of F-rich magmatic-hydrothermal fluids impacted U-Mo mineralization as a ligand.Zircon contains a prominent negative Eu anomaly pointing to a fractionating system rich in plagioclase.Calculated Ti-in-zircon temperatures span 672 ℃ to 1232 ℃ with the temperatures at the high end reflecting interference from mineral inclusions in the zircon grains while the lower temperature values are linked to crystallization.