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目的检测活动性肺结核(ATB)患者血清可溶性髓样细胞触发受体1(s TREM-1)含量并分析其临床意义。方法收集东莞市慢性病防治院确诊的ATB患者78例和健康志愿者40例,全自动血球分析仪检测外周血中性粒细胞和单核细胞绝对值,ELISA检测血清s TREM-1含量,Pearson相关分析其相关性。结果 ATB患者外周血中性粒细胞绝对值,单核细胞绝对值和血清s TREM-1含量均显著增高,且痰涂片结核分枝杆菌(MTB)阳性患者显著高于痰涂片MTB阴性患者,常规抗结核药物治疗前显著高于治疗后。以528.14 pg/m L为血清s TREM-1含量检测截断点时,痰涂片MTB阳性的结核确诊率为100%。Pearson相关性分析显示ATB患者外周血中性粒细胞和单核细胞绝对值均与患者血清s TREM-1含量呈正相关。结论 s TREM-1对ATB的早期预警及预后有重要参考价值。
Objective To detect the serum soluble myeloid cell trigger receptor 1 (s TREM-1) in patients with active pulmonary tuberculosis (ATB) and analyze its clinical significance. Methods 78 cases of ATB patients and 40 healthy volunteers were collected from Dongguan Chronic Disease Prevention and Treatment Center. The absolute value of neutrophil and monocyte in peripheral blood was detected by automatic hematology analyzer. The content of TREM-1 in serum was detected by ELISA, Pearson correlation Analyze its relevance. Results The absolute value of neutrophil, the absolute value of monocyte and the level of serum s TREM-1 in ATB patients were significantly higher than those in sputum smear-positive MTB patients , Conventional anti-TB drugs before treatment was significantly higher than after treatment. At a cutoff of 528.14 pg / m L for serum s TREM-1, sputum smear-positive MTB was 100% confirmed. Pearson correlation analysis showed that the absolute value of neutrophil and monocyte in peripheral blood of patients with ATB was positively correlated with the level of serum TREM-1 in patients with ATB. Conclusion s TREM-1 has an important reference value for the early warning and prognosis of ATB.