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应用成年大鼠肝细胞培养方法检测25例重型病毒性肝炎患者外周血促肝细胞生长活性,结果发现其活性显著高于正常人,慢性活动性肝炎及急性黄疸型肝炎(P<0.01);重肝死亡组促肝细胞生长活性明显高于存活组,肝性脑病组显著高于无肝性脑病组。存活病例随病情的好转其活性下降,死亡组病例随病情加重,昏迷加深其活性进一步增高。结果提示:重肝患者外周血促肝细胞生长活性可能与肝细胞生长因子密切相关,在肝细胞再生调控中具有重要的意义,检测其活性可作为估计预后及探讨肝细胞再生机理的指标。
The hepatocyte growth activity in peripheral blood of 25 patients with severe viral hepatitis was detected by using adult rat hepatocyte culture method. The results showed that the activity was significantly higher than that of normal, chronic active hepatitis and acute jaundice hepatitis (P <0.01) The hepatic cell growth activity in the liver death group was significantly higher than that in the surviving group, and the hepatic encephalopathy group was significantly higher than that in the non-hepatic encephalopathy group. Survival of surviving cases with the improvement of the disease decreased, the death group with the aggravation of illness, coma further deepened its activity. The results suggest that the hepatocyte growth activity in peripheral blood of patients with severe hepatitis may be closely related to hepatocyte growth factor and play an important role in the regulation of hepatocyte regeneration. To test its activity may be used as an index to estimate the prognosis and explore the mechanism of hepatocyte regeneration.