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合成了胡椒酮的衍生物和类似物16种,连同选用的市售药物和试剂4种进行了解痉活性的筛选。初步的临床观察表明消旋1,1′-双异薄荷酮(5) 对支气管痉挛的哮喘有较好的作用,研究了化学结构与解痉活性的关系。
Sixteen derivatives of piperonyl and analogues were synthesized and tested for antispasmodic activity along with four commercially available drugs and reagents. Preliminary clinical observations indicate that racemic 1,1’-bis-menthone (5) has a good effect on asthma with bronchospasm and the relationship between chemical structure and antispasmodic activity.