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目的阐述补体激活与抗磷脂综合征的关系,为临床治疗提供新的治疗靶点。方法查阅大量文献资料进行整理和分析。结果补体在抗磷脂综合征患者中发挥着重要的致病作用,补体的过渡激活是抗磷脂抗体介导习惯性流产和血栓形成的关键环节。结论补体激活在抗磷脂综合征中的作用重大,针对补体的靶向治疗有待临床上大样本资料的进一步证实。
Objective To elucidate the relationship between complement activation and antiphospholipid syndrome and to provide new therapeutic targets for clinical treatment. Methods access to a large number of documents for collation and analysis. Results Complement plays an important pathogenic role in patients with antiphospholipid syndrome. The transitional activation of complement is the key link of antiphospholipid antibody mediated habitual abortion and thrombosis. Conclusion The role of complement activation in antiphospholipid syndrome is significant. The targeted therapy targeting complement has yet to be further confirmed by large clinical samples.