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目的评价奥沙利铂(L-OHP)联合亚叶酸钙(CF)及氟尿嘧啶(5-FU)治疗晚期结直肠癌的疗效和毒副反应。方法51例晚期结直肠癌患者,给予L-OHP130mg/m2静脉滴入,持续2h,第1天;CF:200mg/次,静脉滴入,持续2h,第2~6天;5-FU:500mg/m2,静脉滴入,持续6h,第2~6天。每3周重复1次,用药2个周期后评价疗效。结果51例患者中,完全缓解(CR)2例,部分缓解(PR)17例,稳定(SD)20例,进展(PD)12例,总有效(CR+PR)率:37.2%。毒副反应主要是末梢神经毒性、恶心呕吐、骨髓抑制及静脉炎等。结论L-OHP联合CF/5-FU治疗晚期大肠癌具有较好的疗效,毒副反应可以耐受。
Objective To evaluate the efficacy and toxicity of oxaliplatin (L-OHP) in combination with leucovorin (CF) and fluorouracil (5-FU) in the treatment of advanced colorectal cancer. Methods Fifty-one patients with advanced colorectal cancer were treated with intravenous infusion of L-OHP at 130 mg / m2 for 2 h on the first day, CF: 200 mg / time for 2 h, on the 2nd to 6th days. 5-FU: / m2, intravenous infusion, sustained 6h, 2 to 6 days. Repeat once every 3 weeks, 2 weeks after treatment evaluation of efficacy. Results Among the 51 patients, 2 were complete remission (CR), 17 were partial remission (PR), 20 were stable (SD) and 12 were progressive (PD). The total effective rate (CR + PR) was 37.2%. Toxicity is mainly peripheral neurotoxicity, nausea and vomiting, bone marrow suppression and phlebitis. Conclusion L-OHP combined with CF / 5-FU in the treatment of advanced colorectal cancer has good curative effect and the side effects can be tolerated.