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目的探讨三阴性乳腺癌(TNBC)与非三阴性乳腺癌(NTNBC)的临床病理分类与病理特征。方法 208例乳腺癌患者作为研究对象,根据人表皮生长因子受体2(HER2)、孕激素受体(PR)及雌激素受体(ER)检验结果将其分为TNBC患者50例与NTNBC患者158例。观察TNBC与NTNBC乳腺癌的临床病理特征及病理因素相关性。结果 TNBC与NTNBC在淋巴结转移、发病时间、乳头浸润、TNM分期、病理分型方面比较,差异具有统计学意义(P<0.05);TNBC与NTNBC乳腺癌分型与发病时间、淋巴结转移、TNM分期及病理分型呈正相关(r=0.102、0.103、0.105、0.107,P<0.05)。结论 TNBC具有独特的病理特征,其发病时间、淋巴结转移、TNM分期及病理分型与NTNBC不同,临床应给予足够的重视。
Objective To investigate the clinicopathological classification and pathological features of triple negative breast cancer (TNBC) and non-triple negative breast cancer (NTNBC). Methods Totally 208 breast cancer patients were divided into 50 patients with TNBC and NTNBC patients according to the results of human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR) and estrogen receptor (ER) 158 cases. To observe the clinicopathological characteristics and pathological factors of TNBC and NTNBC breast cancer. Results The TNBC and NTNBC were significantly different in lymph node metastasis, onset time, papillary infiltration, TNM staging and pathological classification (P <0.05). The TNBC and NTNBC classification of breast cancer and its onset time, lymph node metastasis, TNM stage And pathological type was positively correlated (r = 0.102,0.103,0.105,0.107, P <0.05). Conclusion TNBC has a unique pathological features, its onset time, lymph node metastasis, TNM stage and pathological type and NTNBC different clinical attention should be given enough attention.