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1974年作者曾报告一组132例急淋儿童在首次骨髓完全缓解2-3年后停止一切治疗的结果。其中17例在治疗停止时复发而再度治疗。17例均在诱导期以强的松、长春新碱和阿霉素治疗。以后对部分病例用两周的门冬酰胺酶或阿糖胞苷治疗。维持化疗为每周口服氨甲喋呤、每日予6-巯基嘌呤。有脑膜复发者鞘内注射氨甲喋呤;睾丸复发者予病侧睾丸放疗(2400拉德)。对于骨髓第二次缓解至少30个月的儿童,常规双侧睾丸活检以确定是否有完全缓解。结果:17例中16例获得第二次骨髓完全缓解,随访3-5年,中数缓解期10个月(3-58~+个月)。其后在维持化疗时病人全部又复发,8例在骨髓,6例在中枢神经系统(CNS),1例
In 1974, the authors reported the results of a series of 132 children with acute urinary incontinence who stopped all treatment 2-3 years after the first bone marrow was completely relieved. Seventeen of them relapsed and were treated again when the treatment was stopped. 17 cases were induced during the prednisone, vincristine and doxorubicin treatment. After some cases with two weeks of asparaginase or cytarabine treatment. Maintenance chemotherapy for oral administration of methotrexate weekly, to 6 - mercaptopurine. There are meningeal intrathecal injection of methotrexate; testicular recurrence to the side of the testis radiotherapy (2400 rad). For children with a second bone marrow remission for at least 30 months, routine bilateral testis biopsies were performed to determine if there was complete remission. Results: Sixteen of 17 patients achieved complete second bone marrow remission. The patients were followed up for 3-5 years and the median remission period was 10 months (3-58 months). All patients then relapsed after chemotherapy, 8 in the bone marrow, 6 in the central nervous system (CNS), 1