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目的 探讨Ｐ１６ 基因蛋白表达与膀胱移行细胞癌的相关性。方法 采用免疫组化ＳＰ法检测７５ 例膀胱移行细胞癌组织Ｐ１６ 基因表达。结果 Ｐ１６ 蛋白异常表达率为４１ ．３％ （３１／７５） ，Ｐ１６ 阳性表达率与肿瘤病理分级、临床分期有密切关系（ Ｐ＜ ０ ．０５） ，与淋巴结及远处转移无关（ Ｐ＞ ０．０５）。结论 Ｐ１６ 蛋白的异常表达与膀胱癌的恶性程度、浸润性有关。
Objective To investigate the relationship between the expression of P16 protein and transitional cell carcinoma of the bladder. Methods Immunohistochemical SP method was used to detect the expression of P16 gene in 75 cases of bladder transitional cell carcinoma. Results The abnormal expression of P16 protein was 41. 3% (31/75). The positive expression rate of P16 was closely related to tumor grade and clinical stage (P <0.05), but not to lymph node and distant metastasis (P> 0.05). Conclusion The abnormal expression of P16 protein is associated with the malignancy and invasiveness of bladder cancer.