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目的 观察肝硬化患者降钙素基因相关肽 (calcitonin gene related peptide,CGRP)和内皮素(endothelin,ET)血浆浓度变化 ,并探讨其意义。方法 放免法测定 5 4例肝硬化患者和 2 2例正常人血浆 CGRP和 ET浓度 ,双核素肾图技术测定 2 8例肝硬化患者有效肾血浆流量。结果 血浆 CGRP和 ET浓度肝硬化组显著高于正常对照组 ,肝功能 Child A、B、C级各组中浓度依次升高。血浆 CGRP和 ET间存在明显正相关。血浆 CGRP和 ET浓度腹水组明显高于无腹水组 ,有效肾血浆流量下降组明显高于正常组。结论 血浆 CGRP和 ET浓度反映肝硬化严重程度 ,腹水形成或肾有效血浆流量下降时明显升高。CGRP和 ET可能在肝硬化循环系统变化中起一定作用
Objective To observe the changes of plasma concentrations of calcitonin gene related peptide (CGRP) and endothelin (ET) in cirrhotic patients and to explore its significance. Methods The plasma concentrations of CGRP and ET in 54 patients with cirrhosis and 22 normal controls were determined by radioimmunoassay. The effective renal plasma flow in 28 patients with cirrhosis was determined by dual-nephron nephron mapping. Results The levels of plasma CGRP and ET in cirrhotic patients were significantly higher than those in normal controls. The levels of Child A, B and C in each group were increased in turn. There was a significant positive correlation between plasma CGRP and ET. Plasma CGRP and ET concentrations were significantly higher in ascites group than in ascites group, effective renal plasma flow decreased significantly higher than the normal group. Conclusions Plasma CGRP and ET concentrations reflect the severity of cirrhosis, with a significant increase in ascites formation or decrease in effective renal plasma flow. CGRP and ET may play a role in the changes of circulatory system of cirrhosis