目的　探讨预先静脉注射山莨菪碱有无预防大鼠中暑性内毒素血症的作用。方法　实验动物随机分为两组 ,置于 38℃～ 40℃、5 0 %～ 6 0 %相对湿度的热环境中 ,用四道生理记录仪、半导体温度计测平均动脉压和直肠温度 ,并测热应激的生存时间和生存率 ,在严格无菌和去热源的条件下 ,采集门静脉血和颈动脉血 ,用显示基质偶氮法测血浆内毒素含量。结果　热应激过程中 ,实验组和对照组动物肛温持续增加 ,2h后分别达 (4 2 .7± 0 .6 )℃和 (4 3.1± 0 .5 )℃ ,两组比较 ,差异无显著性(P >0 .0 5 ) ,死亡前肛温高达 (4 4.6± 0 .2 )℃和 (4 4.2± 0 .3)℃ ,差异有显著性 (P <0 .0 1)。实验前门静脉血内毒素含量分别为 (4 5 .7± 5 .2 ) pg/ml和 (4 2 .6± 5 .4) pg/ml,外周血内毒素含量分别为 (14.8± 4.5 ) pg/ml和 (13.9± 7.2 )pg/ml,差异均无显著性 (P >0 .0 5 ) ;2h后门静脉血分别增至 (12 2 .2±16 .7)pg/ml和 (15 0 .4± 2 2 .1) pg/ml,而外周血增至 (32 .3± 7.8) pg/ml和 (4 9.7± 10 .2 )pg/ml,明显高于实验前 ,差异有显著性 (P <0 .0 1) ,而且两组之间比较 ,差异也有显著性 (P <0 .0 1)。两组动物心率变化趋势基本相同 ,都是先升后降 ,但实验前后心率变化的差异无显著性 (P >0 .0 5 ) ;实验前两组动? Objective To investigate the effect of intravenous injection of anisodamine on the prevention of endotoxemia in rats. Methods Experimental animals were randomly divided into two groups and placed in a hot environment of 38 ° C to 40 ° C and relative humidities of 50% to 60%. Mean arterial pressure and rectal temperature were measured with a four-channel physiological logger and a semiconductor thermometer, and measured Survival time and survival rate of heat stress, portal vein blood and carotid blood were collected under strict aseptic and deheating conditions, and plasma endotoxin content was measured by azoar method. Results During the heat stress, the rectal temperature in the experimental group and the control group continued to increase, reaching (42.7 ± 0.6) ℃ and (41.1 ± 0.5) ℃ after 2 hours respectively. There was no significant difference between the two groups (P> 0.05), the rectal temperature before death was as high as (4.6 ± 0.2) ℃ and (4.2 ± 0.3) ℃, the difference was significant (P <0.01). The levels of endotoxin in peripheral blood were (45.7 ± 5.2) pg / ml and (42.6 ± 5.4) pg / ml, respectively. The levels of endotoxin in peripheral blood were (14.8 ± 4.5) pg ml and (13.9 ± 7.2) pg / ml respectively, no significant difference was found between the two groups (P> 0.05); after 2 hours, the portal venous blood increased to (122.2 ± 16.7) pg / ml and .4 ± 21.2 pg / ml, while peripheral blood increased to (32.3 ± 7.8) pg / ml and (4.97 ± 10.2) pg / ml, respectively, which were significantly higher than those before the experiment (P <0.01), and the difference between the two groups was also significant (P <0.01). There was no significant difference in heart rate between the two groups before and after the experiment (P> 0.05). Before the experiment, the changes of heart rate were basically the same,