90年代以来 ,一种新的促进药物经皮渗透的方法电穿孔技术 ,被用于一些药物的经皮给药研究中 ,其独特的促渗机理开辟了药物尤其是大分子多肽类药物经皮转运的前景。本文综述了电穿孔技术的一些理论基础、在经皮给药领域中的应用、影响因素以及电穿孔所采用的高压脉冲对皮肤的影响 Since the 1990s, a new method to promote drug transdermal penetration electroporation technology, is used in the study of transdermal drug delivery of some drugs, and its unique mechanism of promoting osmosis has opened up drugs, especially macromolecular peptides, Transit prospects. This article reviews some of the theoretical foundations of electroporation technology, its application in the field of transdermal drug delivery, its influencing factors, and the effects of high-voltage pulses used on electroporation on the skin